Stability and Product–Packaging Compatibility of ORS Formulations: A Comparative Study of Powder Barriers and the Case for Liquid Transition

Bekhzad Yuldashev

Citation: Bekhzad Yuldashev, "Stability and Product–Packaging Compatibility of ORS Formulations: A Comparative Study of Powder Barriers and the Case for Liquid Transition", Universal Library of Business and Economics, Special Issue.

Copyright: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This article examines the factors that determine the stability and product–packaging compatibility of pediatric oral rehydration salts (ORS) in both powder and ready-to-use liquid dosage forms. The relevance of the study is defined by the persistent burden of diarrheal disease in children and by the central role of oral rehydration therapy in preventing severe dehydration. Particular attention is given to the effects of package moisture permeability, seal integrity, and storage conditions on the physicochemical stability of ORS powder blends, as well as to the technological advantages of transition to pre-mixed oral solutions. The paper compares multilayer flexible packaging materials used for powders with bottle-based systems used for liquids. It is shown that, for hygroscopic ORS powders, the highest level of protection is provided by high-barrier laminates incorporating an aluminum layer, whereas for ready-to-use oral solutions the critical issue is the integrity of the primary container closure system rather than moisture transfer through flexible films. As an example of localization in Uzbekistan, the paper additionally considers Regidreyd (dextrose; sodium chloride; potassium chloride; sodium citrate dihydrate), an oral solution manufactured by Samarkand England Eco-Medical in 100 ml, 250 ml, and 500 ml bottles. The concluding argument is that the selection of packaging for pediatric ORS should be determined not only by economic considerations, but by the correspondence between dosage form and container system: high-barrier stick-packs for powders, and sealed bottle-based systems for liquid ready-to-use formulations.


Keywords: Oral Rehydration Salts, Pediatrics, Pharmaceutical Packaging, Drug Stability, Vapor Permeability, Maillard Reaction, Pharmaceutical Market of Uzbekistan, Hygroscopicity, GMP, Stick Pack.

Download doi https://doi.org/10.70315/uloap.ulbec.2022.002