Evaluation of the Glucose-Regulating Function of a Momordica charantia Compound Capsule

Tzu-Chin Wu, Mon-Chien Lee, Yi-Ju Hsu, Chi-Chang Huang, Jia-Xing Wang, Yu-Jou Chien

Citation: Tzu-Chin Wu, Mon-Chien Lee, Yi-Ju Hsu, Chi-Chang Huang, Jia-Xing Wang, Yu-Jou Chien, "Evaluation of the Glucose-Regulating Function of a Momordica charantia Compound Capsule", Universal Library of Medical and Health Sciences, Volume 03, Issue 04.

Copyright: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Diabetes mellitus is a prevalent metabolic disorder characterized by impaired glucose regulation and insulin resistance. Developing functional foods with blood glucose–modulating potential is crucial for diabetes prevention and management. Methods: A diabetic rat model was induced by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg) combined with nicotinamide (230 mg/kg) to evaluate the hypoglycemic effects of a Momordica charantia compound capsule. Sixty male Sprague-Dawley rats (8 weeks old) were randomly divided into a control group and diabetic groups (DM, DM-1X, DM-2X, and DM-5X). The treatment groups received oral supplementation for eight weeks. Fasting blood glucose, oral glucose tolerance test (OGTT), serum insulin, 24-hour urine volume, and urinary glucose were assessed. Results: STZ/NA-induced diabetic rats exhibited significantly elevated fasting blood glucose, reduced insulin secretion, and impaired glucose tolerance (p < 0.05). After eight weeks of supplementation, all treatment groups showed significant decreases in fasting blood glucose and OGTT area under the curve, along with improved insulin sensitivity and glucose tolerance (p <0.05). Conclusion: The Momordica charantia compound capsule significantly improved glycemic control and insulin resistance in diabetic rats, demonstrating its potential as a functional food for blood glucose regulation. The recommended adult dosage is four capsules per day (497 mg per capsule), which may help support glycemic balance and metabolic health.


Keywords: Momordica Charantia, Blood Glucose Regulation, Insulin Resistance, Streptozotocin, Functional Food.

Download doi https://doi.org/10.70315/uloap.ulmhs.2025.0304004