Evaluation of the Anti-Aging Efficacy of Repeat Juvenile Tablets

Tzu-Chin Wu, Mon-Chien Lee, Yi-Ju Hsu, Chi-Chang Huang, Jia-Xing Wang, Yu-Jou Chien

Citation: Tzu-Chin Wu, Mon-Chien Lee, Yi-Ju Hsu, Chi-Chang Huang, Jia-Xing Wang, Yu-Jou Chien, "Evaluation of the Anti-Aging Efficacy of Repeat Juvenile Tablets", Universal Library of Medical and Health Sciences, Volume 04, Issue 01.

Copyright: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: Aging is a physiological decline triggered by various internal and external factors, characterized by organ degeneration and diminished physiological functions. Developing health supplements with anti-aging properties is of significant importance in addressing aging-related functional decline and diseases. Methods: This study utilized 40 male and 40 female 12-month-old aging C57BL/6 mice. Within each sex, mice were randomly assigned to four groups (n=10 per group) based on body weight: a control group, and low, medium, and high-dose groups. Following 12 weeks of continuous administration, tests were sequentially conducted to evaluate memory and learning capabilities, aging-related biomarkers in the brain and liver, and antioxidant capacity. Results: Experimental data from the Morris water maze test indicated that the escape latency (time to reach the platform) for the low, medium, and high-dose Repeat Juvenile groups was significantly lower than that of the control group (p < 0.05). Furthermore, supplementation with Repeat Juvenile significantly reduced aging-related biomarkers in the brain and liver while markedly enhancing antioxidant capacity. Finally, in survival assays, supplementation at 1X, 2X, and 5X dosages significantly extended the median survival, mean lifespan, and maximum lifespan (p < 0.05) in both male and female Drosophila (fruit fly) survival curves. Conclusion: Repeat Juvenile tablets demonstrate significant antioxidant capacity and a reduction in aging markers in aging mouse models, suggesting substantial health benefits for delaying senescence. It is recommended that a daily supplementation of 3,200 mg for adults may provide efficacious anti-aging benefits.


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Download doi https://doi.org/10.70315/uloap.ulmhs.2026.0401003