Mesotherapy and Biorevitalization Within the Prejuvenation Paradigm: A Comprehensive Analysis of Efficacy and Clinical Protocols for Young Facial Skin

Bagdasarian Goar

Citation: Bagdasarian Goar, "Mesotherapy and Biorevitalization Within the Prejuvenation Paradigm: A Comprehensive Analysis of Efficacy and Clinical Protocols for Young Facial Skin", Universal Library of Medical and Health Sciences, Volume 04, Issue 01.

Copyright: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study examines the use of injectable modalities - mesotherapy and biorevitalization - in the therapeutic management of patients aged 18–35 years. The evidentiary foundation of the research is constructed from a systematized review of specialized literature, clinical observations, and market statistics for 2023–2024. The conceptual architecture of the paper is organized around a paradigmatic shift from predominantly corrective aesthetic medicine toward a preventive model of care aligned with the concept of prejuvenation, wherein the priority is early intervention aimed at preserving the structural and functional potential of the skin and reducing the likelihood of developing pronounced age-associated changes. The report’s core propositions elucidate the molecular and biological mechanisms of action of polynucleotides (PDRN), amino acid clusters, and hyaluronic acid, taking into account the physiological characteristics of the young dermis. The biochemical and cellular effects of these substances are considered in detail in relation to the regulation of reparative processes, the metabolic activity of the dermal matrix, and the maintenance of hydration parameters that determine tissue quality at preclinical stages of involution. In the analytical section, classes of products and their therapeutic relevance are systematically compared in addressing the most frequent clinical objectives within this age cohort. Outcome assessment is based on correlating clinical endpoints with the dynamics of objective indicators, which makes it possible to substantiate the selection of composition and injection technique in accordance with the leading pathogenetic factor.


Keywords: Prejuvenation, Mesotherapy, Biorevitalization, Hyaluronic Acid, Polynucleotides (PDRN/PN), Skin Quality, Post-Acne, Clinical Protocols.

Download doi https://doi.org/10.70315/uloap.ulmhs.2026.0401004