Practices in the Management of Patients with Multiple Organ Failure in the Intensive Care Unit

Citation: Dobrenko Olga, "Practices in the Management of Patients with Multiple Organ Failure in the Intensive Care Unit", Universal Library of Medical and Health Sciences, Volume 03, Issue 03.

Copyright: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This article examines practices in the management of patients with multiple organ failure in the intensive care unit based on a comprehensive analysis of current clinical guidelines, epidemiological studies, and results of randomized controlled trials. This work aims to systematize and integrate epidemiological, pathophysiological, and clinical recommendation data into a unified decision-making algorithm for treating patients with multiple organ failure, as well as to assess the effectiveness of organ-targeted protocols and modern prognostic biomarkers. The relevance of the study is justified by the high prevalence of multiple organ failure among intensive care patients, elevated in-hospital mortality, and significant economic burden, all of which demand standardization of clinical practice and the search for new solutions for timely detection and correction of the syndrome. The novelty of the work lies in the inclusion of early ultrasound stratification of hemodynamics and volume status in the management algorithm, the use of dynamic markers such as lactate clearance and bedside ultrasound, and the integration of artificial intelligence algorithms to predict the risk of MOF development 24 hours before clinical manifestation. The main conclusions of the work are as follows: the primary stage of treatment remains volume-limited hemodynamic resuscitation with monitoring of lactate clearance and dynamic preload indices; subsequently, targeted vasopressors and inotropes are applied according to the Surviving Sepsis Campaign recommendations; organ-targeted support includes ultrasound stratification of congestion, lung-protective ventilation with early prone positioning, and clear criteria for ECMO initiation; optimal timing for CRRT initiation is determined on a personalized basis with a preference for regional citrate anticoagulation and the use of biomarkers. This article will be useful for intensivists as well as specialists in critical care medicine, anesthesiology, nephrology, and clinical engineering.

Keywords: Multiple Organ Failure; Intensive Care; Hemodynamic Resuscitation; Extracorporeal Support; Ultrasound Stratification.

https://doi.org/10.70315/uloap.ulmhs.2025.0303007